What this means
This trial plans to compare exercise, a diabetes drug called semaglutide, both, or standard care. It has not started, so it does not yet show whether either helps thinking or brain health.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 65 and over
- Where
- 1 site
The science
- Registered title
- Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
- Trial ID
- NCT07485062 ↗
- Phase
- PHASE 4
- Study type
- interventional
- Conditions
- Type 2 Diabetes, Cognitive Decline in Older Adults
- What is tested
- semaglutide, Moderate-Intensity Resistance Exercise, Balance and Tone (BAT) Exercise
- Sponsor
- Western University, Canada
- Ages
- 65 Years to no maximum
- Dates
- First posted Mar 20, 2026 · updated Aug 20, 2026
Registry summary
Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and physical function in this population.
The MOTIVATE study is a randomized clinical trial designed to examine the effects of supervised exercise and diabetes treatment with semaglutide, alone or in combination, on cognitive function, physical health, and brain-related outcomes in older adults with Type 2 diabetes. Participants will be assigned to one of four study groups involving exercise training, control exercise, semaglutide treatment, or standard diabetes care.
Participants will complete supervised exercise sessions three times per week for 32 weeks, with some participants also receiving weekly semaglutide injections for 16 weeks. Assessments will include cognitive testing, physical and functional measures, blood-based metabolic markers, and brain imaging. This study aims to improve understanding of how exercise and diabetes treatments may support brain health in older adults with Type 2 diabetes.
Sites (1)
- Western University, London, Ontario, Canada