What this means
Researchers plan to track daily stress, thinking skills, and blood markers of inflammation in older adults in Seoul. This is a planned study, so it does not yet show any results or answers.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60 and over
- Where
- 1 site
The science
- Registered title
- Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
- Trial ID
- NCT07485387 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder
- Sponsor
- Korea University
- Ages
- 60 Years to no maximum
- Dates
- First posted Mar 20, 2026 · updated Mar 20, 2026
Registry summary
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are:
Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time?
Participants will:
Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year
This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.
Sites (1)
- Korea University, Seoul, Select One..., South Korea