What this means
This trial is testing whether a brain stimulation method plus exercise can improve thinking and walking in frail older adults. It has not reported results, so we do not yet know if it works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60–90
- Where
- 1 site
The science
- Registered title
- A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
- Trial ID
- NCT07497334 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Frailty at Older Adults, Mild Cognitive Impairment
- What is tested
- Theta burst stimulation, Aerobic exercise
- Sponsor
- The Hong Kong Polytechnic University
- Ages
- 60 Years to 90 Years
- Dates
- First posted Mar 27, 2026 · updated Sep 30, 2026
Registry summary
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are:
- Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation?
- What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?
Sites (1)
- The Hong Kong Polytechnic University, Department of Rehabilitation Sciences, Hong Kong, Hong Kong