What this means
A study plans to test whether exercise lowers damage and inflammation in fat inside muscle as people age. The study has not started, so it cannot yet show any results.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 65–80 · 16 older adults aged 65-80
- Where
- 1 site, including Missouri
The science
- Registered title
- IMAT Quality in Aging
- Trial ID
- NCT07506681 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Aging
- What is tested
- Calf muscle strengthening
- Sponsor
- Washington University School of Medicine
- Ages
- 65 Years to 80 Years
- Dates
- First posted Apr 2, 2026 · updated Aug 18, 2026
Registry summary
This study will test the central hypothesis that fat within the muscle, or intramuscular adipose tissue (IMAT), exhibits elevated damage and pro-inflammatory signaling with aging, both of which are reduced by progressive resistance exercise (PRE). Sixteen older adults 65-80 years old will be recruited and complete a 12 week calf PRE intervention. Calf muscle strength, composition (measured by computed tomography) and muscle biopsies will be collected before and after the intervention. Histology, transcriptomic and secretomic tests will be completed to assess signs of damage and inflammation.
Sites (1)
- Washington University, St Louis, Missouri, United States