What this means
This is a planned study that has not started enrolling people yet. It will test whether the two products help vaginal symptoms and the vaginal microbiome, and no results are posted.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 40–70
- Where
- 1 site, including New York
The science
- Registered title
- Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV
- Trial ID
- NCT07526948 ↗
- Phase
- PHASE 4
- Study type
- interventional
- Conditions
- Menopausal Complaints, Vaginal Atrophy, Genitourinary Symptoms, HIV (Human Immunodeficiency Virus), Menopause Related Conditions, Vaginitis, Perimenopause
- What is tested
- Vaginal estradiol tablets, Vaginal moisturizer
- Sponsor
- Albert Einstein College of Medicine
- Ages
- 40 Years to 70 Years
- Dates
- First posted Apr 14, 2026 · updated Jul 28, 2026
Registry summary
This is a research study about the effects of vaginal estradiol compared to moisturizer on vaginal symptoms of menopause and the microbiome in women with HIV. This research study aims to understand how vaginal products affect the aging of the female genital tract in women living with HIV who are menopausal or perimenopausal and have vaginal or urinary symptoms. There is a comparison group of women who are living without HIV. Participants with HIV and vaginal or urinary menopausal symptoms (e.g., dryness, irritation, soreness, itching, pain with sex, dysuria, urgency, or frequent urinary tract infections) will be asked to apply vaginal estradiol or a vaginal moisturizer (Replens). Participants who have vaginal or urinary menopausal symptoms and do not have HIV will receive vaginal estradiol.
Sites (1)
- Albert Einstein College of Medicine, The Bronx, New York, United States