What this means
Researchers plan to see how a senior milk powder with synbiotics changes gut bacteria over at least 28 days. This study is only exploratory and does not show whether the powder works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 40–65 · About 125 adults aged 40 to 65 in Singapore, aiming for 100 who finish; trial is recruiting, no results yet
- Where
- 1 site
The science
- Registered title
- DORA - A Study Using Digital Health Tools/Platform to Explore the Impact of the Consumption of Senior Milk Powder Containing Synbiotics on the Gut micRobiome in Healthy Aging Individuals
- Trial ID
- NCT07575529 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Healthy Adult Participants, Gut Microbiomes, AI
- What is tested
- Synbiotic Nutritional Product
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
- Ages
- 40 Years to 65 Years
- Dates
- First posted May 8, 2026 · updated Aug 3, 2026
Registry summary
The DORA study is a single-arm, open-label, interventional exploratory study designed to evaluate the impact of a synbiotic-containing senior milk powder on the gut microbiome and selected biological, physiological, and digital health parameters in community-living adults in good health.
The study enrolls adults aged 40 to 65 years and aims to investigate changes in gut microbial composition, with a primary focus on butyrate-producing microbial taxa, following at least 28 days of study product consumption. Secondary and exploratory objectives include assessment of stool metabolites, blood-based biomarkers, bowel patterns, sleep quality, physical activity, cognitive function, dietary patterns, and quality of life.
Approximately 125 participants will be recruited in Singapore to achieve 100 study completers. Following informed consent and screening, participants undergo a baseline observation period of 14 days during which physiological and lifestyle data are collected using wearable digital health devices. Baseline assessments also include blood sampling, stool collection for microbiome analysis, digital imaging and videography, and completion of validated questionnaires.
After completion of baseline assessments and collection of the first stool sample, participants initiate consumption of the study product, a senior milk powder containing a defined synbiotic formulation. The study product is consumed twice daily for a minimum of 28 days and up to 35 days to allow completion of study assessments.
Participants return for end-of-intervention assessments following the study product phase, including repeat biological sampling, physical and digital assessments, and questionnaires. Stool microbiome profiles and other exploratory outcomes are compared between baseline and post-intervention time points.
This exploratory study is intended to generate feasibility data and hypotheses regarding the effects of synbiotic nutritional intervention and the integration of biological and digital health data in the context of healthy aging.
Sites (1)
- Woodland Hospital, Singapore, Singapore