What this means
This is a plan for a study that has not started recruiting people yet. It will collect skin and blood samples to look at how cells change with age.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 18–90
- Where
- 2 sites
The science
- Registered title
- Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
- Trial ID
- NCT07596615 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Aging, Inflammation, Healthy Ageing
- What is tested
- Skin biopsy and venous blood sampling
- Sponsor
- Mario Negri Institute for Pharmacological Research
- Ages
- 18 Years to 90 Years
- Dates
- First posted May 19, 2026 · updated May 19, 2026
Registry summary
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups. Skin-derived fibroblasts and peripheral blood mononuclear cells (PBMCs) will be isolated from skin biopsy and blood samples to characterize age-related cellular and molecular changes and to test experimental therapeutic strategies identified in preclinical studies. Serum, plasma, and whole-blood RNA will be used for protocol-defined analyses of circulating inflammatory mediators and systemic transcriptional signatures related to inflammation, type I interferon activation, mitochondrial stress response, immune aging, and senescence-associated pathways.
Sites (2)
- Laboratory for Targeted Therapy in Autoimmune Diseases, Bergamo, BG, Italy
- Centro di Ricerche Cliniche per le Malattie Rare "Aldo e Cele Daccò", Ranica, BG, Italy