What this means
A trial is testing if a light treatment on the head can improve blood flow in the brain and thinking skills. Results are not yet reported, so it is not known if it works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 55–95
- Where
- 1 site, including Oklahoma
The science
- Registered title
- Using Light Therapy for Mild Cognitive Impairment
- Trial ID
- NCT07651787 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Mild Cognitive Impairment (MCI), Amyloid Pathology
- What is tested
- Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation, Sham Vielight Neuro RX-Duo device -Sham transcranial photobiomodulation
- Sponsor
- University of Oklahoma
- Ages
- 55 Years to 95 Years
- Dates
- First posted Jun 16, 2026 · updated Jun 16, 2026
Registry summary
The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in people with mild cognitive impairment (MCI). The main questions it aims to answer are:
- Does tPBM enhance cognitive function and cerebral hemodynamic responses during memory and finger tapping tasks?
- Does tPBM reduce oxidative stress, inflammation, and mitigate brain cell damage?
- Is cognitive improvement linked to amyloid status, greater cerebral hemodynamic response, and lower levels of brain inflammation and oxidative stress? Researchers will compare an active tPBM treatment arm to a sham treatment arm to see if tPBM leads to measurable improvements in brain activity and cognitive function compared to no active stimulation.
Participants will:
- Receive a 20-minute-long active tPBM or sham stimulation session once per day, 6 times per week, for 12 weeks.
- Complete questionnaires and an iPad-based cognitive testing protocol.
- Complete memory and motor tasks while their brain activity is measured using non-invasive techniques: simultaneous functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG). Dynamic analysis of the vessels in the eye will also be performed based on eligibility. Transcranial Doppler (TCD) flowmetry is optionally performed.
- Provide blood samples to test for biomarkers of inflammation, oxidative stress, and brain cell damage.
Sites (1)
- University of Oklahoma Health Campus, Oklahoma City, Oklahoma, United States