What this means
This is a trial plan that has not started taking patients yet, so no results exist. It will test whether warmer temperature control during surgery lowers slow thinking recovery problems.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 65 and over
- Where
- 2 sites
The science
- Registered title
- Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery
- Trial ID
- NCT07655687 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Elderly Patients, Cancer Surgery, Hypothermia, Accidental, Targeted Temperature Management, Delayed Neurocognitive Recovery
- What is tested
- Target temperature management, Routine thermal management
- Sponsor
- Peking University First Hospital
- Ages
- 65 Years to no maximum
- Dates
- First posted Jun 18, 2026 · updated Jun 23, 2026
Registry summary
With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is associated with prolonged hospital stay, raised complications, and impaired quality of life. Intraoperative hypothermia occurs in 57.1%-78.6% of patients undergoing major cancer surgery, especially in the elderly. Studies show that intraoperative hypothermia suppresses immune function, interferes with anesthetic metabolism, and delays anesthesia emergence. All these may be correlated with the occurrence of early postoperative dNCR. This study aims to verify whether intraoperative targeted temperature management (target core temperature: 36.8°C) compared with conventional temperature management (core temperature: 35.5°C) can reduce the incidence of dNCR in older patients undergoing major cancer surgery.
Sites (2)
- Peking University First Hospital, Beijing, Beijing Municipality, China
- Peking University Shenzhen Hospital, Shenzhen, Guangdong, China