What this means
This is a planned study of aspirin in children with clots in superficial vein growths. It has not started recruiting, and no results have been posted yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 6–17
- Where
- 6 sites
The science
- Registered title
- Acetylsalicylic Acid Versus Placebo as an add-on Treatment to Local Non-steroidal Anti-inflammatory Drug for the Management of Thrombotic Episodes in Superficial Venous Malformations in Children Aged 6 to 17 Years.
- Trial ID
- NCT07663825 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Venous Malformation, Low Flow, Venous Malformations
- What is tested
- AAS at anti-inflammatory doses from 3 days to 14 days., Placebo from 3 days to 14 days., Application of Diclofenac gel 1% twice a day
- Sponsor
- University Hospital, Tours
- Ages
- 6 Years to 17 Years
- Dates
- First posted Jun 23, 2026 · updated Jun 23, 2026
Registry summary
Superficial venous malformations (SVMs) are rare congenital anomalies that present as bluish masses. These masses may be focal, with limited skin involvement, or segmental, with more extensive involvement. They may be associated with syndromic conditions such as blue rubber nevus syndrome.
SVMs are characterised by a progressive worsening course, with repeated episodes of superficial venous thrombosis occurring. These episodes become more frequent over time, causing acute, intense and often highly debilitating pain.
To limit progression and in cases of functional impairment, long-term treatments may be offered. These include venous compression, targeted therapies such as mTOR inhibitors, and, where possible, surgical treatment or sclerotherapy.
However, the management of intra-SVM superficial venous thrombosis is not currently standardised, especially in the pediatric population. This study aims to evaluate the benefits of Acetylsalicylic acid (ASA) as an add-on treatment to local non-steroidal anti-inflammatory drug for the management of thrombotic episodes in superficial venous malformations in children aged 6 to 17 years.
Sites (6)
- Centre Hospitalier Universitaire d'Angers, Angers, France
- Centre Hospitalier Universitaire de Brest, Brest, France
- AP-HM, Marseille, France
- Centre Hospitalier Universitaire de Nantes, Nantes, France
- AP-HP, Paris, France
- Centre Hospitalier Universitaire de Rennes, Rennes, France