What this means
This study will follow people aged 60 and older over time. It will look for signs linking aging immunity to infections, but it has not reported results yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 60 and over
- Where
- 1 site
The science
- Registered title
- Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort
- Trial ID
- NCT07672522 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Immunosenescence
- Sponsor
- Huashan Hospital
- Ages
- 60 Years to no maximum
- Dates
- First posted Jun 29, 2026 · updated Aug 4, 2026
Registry summary
This prospective observational cohort study aims to investigate the relationship between immunosenescence and infectious diseases in older adults. Individuals aged 60 years and older, including elderly patients with infections and healthy controls, will be enrolled and followed longitudinally.
Clinical information, laboratory test results, and health assessment data will be collected. Biological specimens, including peripheral blood, urine, stool, sputum, and nasopharyngeal swabs, will be obtained during enrollment and follow-up. Participants will undergo regular assessments of health status, infection events, and aging-related clinical characteristics.
The study will evaluate age-related changes in immune function, immune cell composition, immune receptor repertoires, epigenetic characteristics, metabolic profiles, and respiratory and gut microbiota. By integrating clinical and multi-omics data, the study aims to identify biomarkers associated with immunosenescence, susceptibility to infection, disease severity, and clinical outcomes in older adults.
The results are expected to improve understanding of the mechanisms linking aging, immune dysfunction, and infectious diseases, and to support the development of predictive models and preventive strategies for infection management and healthy aging in elderly populations.
Sites (1)
- Huashan Hospital, Shanghai, Shanghai Municipality, China