What this means
This is a plan for a study, and no results have been posted yet. It will look at mood, inflammation, and brain age in adults with bipolar disorder.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–65
- Where
- 1 site, including Massachusetts
The science
- Registered title
- The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
- Trial ID
- NCT07699445 ↗
- Phase
- PHASE 4
- Study type
- interventional
- Conditions
- Bipolar Depression Depressed Phase, Obesity & Overweight
- What is tested
- Lumateperone 42 mg
- Sponsor
- Massachusetts General Hospital
- Ages
- 18 Years to 65 Years
- Dates
- First posted Jul 13, 2026 · updated Sep 11, 2026
Registry summary
This research study examines how a medication called lumateperone may affect mood symptoms, and inflammation in adults with bipolar disorder over approximately 6 weeks. An MRI scan to calculate biological age of the brain will also be obtained at the start of the study.
Sites (1)
- Massachusetts General Hospital, Boston, Massachusetts, United States