What this means
This is a plan for a study that has not started yet, and no results are posted. It tests whether a drug given before breathing exercises improves muscle plasticity, which is the brain's ability to change.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 40–79
- Where
- Not listed
The science
- Registered title
- Enhancing Rehabilitation in Aging Study (ERAS)
- Trial ID
- NCT07704385 ↗
- Phase
- PHASE 1 / PHASE 2
- Study type
- interventional
- Conditions
- Adults
- What is tested
- Istradefylline 20 mg, Placebo, Acute Intermittent Hypoxia (AIH)
- Sponsor
- University of Florida
- Ages
- 40 Years to 79 Years
- Dates
- First posted Jul 15, 2026 · updated Jul 15, 2026
Registry summary
Acute Intermittent Hypoxia (AIH) is a rehab approach attributed to serotonin. AIH signaling also occurs via adenosine, and the pathways inhibit each other. Increased neural adenosine in aging may stymie AIH plasticity. The hypothesis is pre-treatment with adenosine 2A receptor inhibition (A2AI) enhances AIH effects on motor plasticity in unaffected adults. AIH exposures will be paired with A2AI or placebo, with a 4-week washout. Primary outcome measures include inspiratory and grip strength.