What this means
Researchers plan to give psilocybin, a drug from mushrooms, to people aged 60 to 80. They want to see if it affects aging signs, thinking, and purpose in life. No results have been posted yet, so we do not know the answers.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 60–80 · Up to 50 older adults, not yet enrolled
- Where
- 1 site, including Colorado
The science
- Registered title
- Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
- Trial ID
- NCT07719088 ↗
- Phase
- PHASE 1
- Study type
- interventional
- Conditions
- Aging, Longevity, Biomarkers of Aging
- What is tested
- Psilocybin (Usona Institute)
- Sponsor
- Charles Raison
- Ages
- 60 Years to 80 Years
- Dates
- First posted Jul 22, 2026 · updated Oct 13, 2026
Registry summary
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults.
Up to 50 participants will be enrolled aged 60-80 who will be randomized with equal allocation to one of four intervention groups: (1) receipt of one 25 mg dose of psilocybin; (2) receipt of two 25 mg doses of psilocybin separated by four weeks; (3) receipt of three 25 mg doses, with each dose separated by four weeks; or (4) wait-list comparator condition that does not receive psilocybin. Biomarkers of aging, cognitive performance, and behavioral measures will be assessed at baseline and longitudinally over a 12-month follow-up period. The primary endpoint occurs at the Week 16 visit. Participants randomized to the wait-list condition will be offered a single 25 mg dose of psilocybin following conclusion of the 12-month follow-up period.
Findings from this Phase I study will inform dose selection for a Phase II study should results indicate a potential impact of psilocybin on relevant study endpoints.
Sites (1)
- Vail Health Behavioral Health, Edwards, Colorado, United States