What this means
This trial plans to test whether daily olive oil affects heart and brain events over five years. It has not started recruiting, so it cannot yet show any result.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 50 and over · 1,324 people living with HIV, aged 50 to 75 (planned)
- Where
- 1 site
The science
- Registered title
- Effect of Extra Virgin Olive Oil Consumption on the Occurrence of Cardiovascular Events in Population Living With HIV
- Trial ID
- NCT07761819 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- HIV - Human Immunodeficiency Virus
- What is tested
- The patients must ingest 50 mL of extra virgin olive oil daily
- Sponsor
- Fundacion SEIMC-GESIDA
- Ages
- 50 Years to no maximum
- Dates
- First posted Aug 12, 2026 · updated Aug 12, 2026
Registry summary
Study Summary: OLEUM VIHTAEGeneral Information Sponsor: Fundación SEIMC - GESIDA Study Title: Effect of Extra Virgin Olive Oil (EVOO) consumption on the occurrence of cardiovascular events in people living with HIV.
Protocol Code: GESIDA 12725 (Version 2.0, Jan 13, 2026) Study Design: National, multicenter, randomized, open-label clinical trial. Intervention Product: Extra Virgin Olive Oil (EVOO). Estimated Enrollment: 1,324 participants (662 per arm). Study Duration: Approximately 60 months (5 years) per participant. Objectives
Primary Objective:
To analyze the incidence of a composite index of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE), including acute coronary syndrome, peripheral arterial disease, coronary/cerebral/peripheral revascularization, cerebrovascular disease, and cardiovascular or cerebrovascular death.
Secondary Objectives:
Incidence of individual cardiovascular events (Stroke, TIA, Heart Failure, Atrial Fibrillation).
All-cause and cardiovascular mortality. Changes in metabolic and physical parameters (weight, blood pressure, glucose, lipid profile).
Development of new comorbidities (HTA, DM2, Obesity) and initiation of related treatments.
Exploratory sub-studies: Changes in gut microbiota, epigenetic aging markers, inflammation panels (96 cytokines), and urinary hydroxytyrosol levels.
Study Population
Key Inclusion Criteria:
HIV-1 infected individuals (diagnosed ≥ 1 year). Age: 50 to 75 years. On Antiretroviral Therapy (ART) ≥ 1 year with suppressed viral load (\<50 copies/mL) for at least 6 months.
Presence of at least one cardiovascular risk factor (HTA, DM2, high LDL, low HDL, smoking, or family history).
Willingness to modify diet and no intolerance to EVOO.
Key Exclusion Criteria:
Pre-existing ischemic heart disease, cerebrovascular disease, or peripheral arterial disease.
Calculated cardiovascular risk (RV10 ASCVD) \< 5%. Life expectancy \< 1 year or inability to complete the study. Severe comorbidities: Stage C Cirrhosis, end-stage renal failure, dementia, or active malignancy.
Current high EVOO intake (≥30 mL/daily). Treatment Plan
Participants will be randomized (1:1 ratio) into two groups:
EVOO Group: Daily intake of 50 mL of Extra Virgin Olive Oil. Control Group: Continuation of their usual diet (verified as not rich in EVOO). Statistical Analysis \& Monitoring Primary Endpoint: Proportion of patients meeting the composite cardiovascular morbidity/mortality index at 5 years.
Methodology: Analysis by protocol and intention-to-treat (ITT) using SPSS v28. Generalized linear models for repeated measures, adjusted for covariates.
Interim Analysis: Planned for Year 2 and Year 4. Ethics Board (Board Affiliation): CEIm Hospital Costa del Sol, Marbella, Spain.
Sites (1)
- Hospital Universitario Costa del Sol, Marbella, Málaga, Spain