What this means
This study has not started recruiting people yet, so no results exist. It will compare how a single bout of aerobic exercise affects brain fluid flow in younger and older adults.
Plain-English summary written by an AI model from the registry listing.
- Status
- Opening soon
- Who can join
- Ages 25–75
- Where
- Not listed
The science
- Registered title
- Aging and Exercise Impacts on Glymphatic Function
- Trial ID
- NCT07775196 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Aging and Exercise Impacts on Glymphatic Function
- What is tested
- Acute Aerobic exercise
- Sponsor
- University of Texas Southwestern Medical Center
- Ages
- 25 Years to 75 Years
- Dates
- First posted Aug 20, 2026 · updated Oct 5, 2026
Registry summary
This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session.
Hypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.