What this means
A trial is testing whether a home exercise plan before surgery improves fitness and immune and heart health. It is still enrolling, so no results are available yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18 and over
- Where
- 2 sites
The science
- Registered title
- Physical Activity and Healthy Aging: Promoting Cardio-metabolic Capacity to Fight Chronic Inflammation and Improve Outcomes in Breast Cancer Patients (PhActHealth Study)
- Trial ID
- NCT07776951 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Breast Cancer
- What is tested
- Pre-habilitation exercise program
- Sponsor
- University of Milan
- Ages
- 18 Years to no maximum
- Dates
- First posted Aug 20, 2026 · updated Aug 20, 2026
Registry summary
PhActHealth is a multicenter randomized controlled trial enrolling women with newly diagnosed luminal B or triple-negative breast cancer (BC) who are candidates for neoadjuvant therapy. The study aims to investigate the effects of a preoperative, unsupervised exercise training program on exercise capacity, as well as on immune response, autonomic nervous system (ANS) regulation, cardiovascular health, and tumor aggressiveness prior to surgical removal.
Participants are randomly assigned to either an intervention group or a control group. All patients receive lifestyle counseling, while those in the intervention group additionally follow a personalized aerobic and resistance exercise program throughout the neoadjuvant treatment period before surgery.
The primary outcome is the improvement in exercise capacity. The secondary outcomes are tumor-specific and systemic responses to the intervention, evaluated by analyzing molecular, metabolic, and inflammatory markers, as well as clinical and functional parameters.
Sites (2)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
- University of Urbino "Carlo Bo", Urbino, Italy