What this means
Researchers will check whether tiny living things in the gut and mouth differ by thinking health. This study has not reported any results yet, so it does not show any link.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18 and over
- Where
- 1 site, including Florida
The science
- Registered title
- Microbiome in Aging of Gut and Brain
- Trial ID
- NCT07799402 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Sponsor
- University of South Florida
- Ages
- 18 Years to no maximum
- Dates
- First posted Sep 2, 2026 · updated Sep 21, 2026
Registry summary
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
The study includes young healthy adults, cognitively healthy older adults, older adults with mild cognitive impairment (MCI), and older adults with Alzheimer's disease or related dementia. At the baseline visit, participants complete assessments of medical history, cognitive function, physical function, and diet and provide biological samples that may include stool, saliva, oral swabs, blood, and urine.
Researchers will study the gut and oral microbiome and related biological factors, including metabolites and markers of intestinal permeability and inflammation, to determine whether these measures differ according to cognitive status.
Young healthy adults, cognitively healthy older adults, and participants with MCI will be followed annually for up to 5 years to evaluate changes in the microbiome and cognitive function over time. Participants with Alzheimer's disease or related dementia will participate in the baseline assessment only.
No drug, treatment, or other research intervention is assigned as part of this study.
Sites (1)
- Department of Neurosurgery and Brain and Spine and Faculty of USF Center for Microbiome Re-search, Microbiomes Institute, Tampa, Florida, United States