What this means
A trial will test whether freezing sperm preserves quality and DNA features that may change with a man's age. It has not reported results yet, so it does not show whether freezing works.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 18–65
- Where
- 1 site
The science
- Registered title
- Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging
- Trial ID
- NCT07814235 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Aging, Epigenetic Aging, Infertility, Assisted Reproduction Technologies, Male Fertility
- Sponsor
- IVI Murcia
- Ages
- 18 Years to 65 Years
- Dates
- First posted Sep 10, 2026 · updated Sep 10, 2026
Registry summary
This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age. Men aged 18 years and older will provide a semen sample and a blood sample for laboratory analysis. Each semen sample will be divided into fresh, slow-frozen, and vitrified aliquots. The study will compare sperm quality (as assessed by computer-assisted sperm analysis), DNA methylation profiles, DNA fragmentation, sperm telomere length before and after cryopreservation. The effects of age on these parameters will also be assessed. The impact of age on seminal plasma extracellular vesicle composition and blood cell telomere length will also be analysed. The goal is to determine whether sperm cryopreservation may represent a strategy for preserving sperm characteristics associated with younger paternal age.
Sites (1)
- IVI Murcia, Murcia, Murcia, Spain