What this means
This is a planned study that is still recruiting people, so it has no results yet. It will look at how two nerve pathways that control leg movement change with age and spinal cord injury.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 19–85
- Where
- 1 site, including Illinois
The science
- Registered title
- Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury
- Trial ID
- NCT07814313 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Healthy Control, Spinal Cord Injury
- What is tested
- CST PAS, RST PAS, sham PAS
- Sponsor
- Shirley Ryan AbilityLab
- Ages
- 19 Years to 85 Years
- Dates
- First posted Sep 10, 2026 · updated Oct 14, 2026
Registry summary
This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments. Experiment 1 will assess corticospinal and reticulospinal tract transmission to lower-limb muscles in older adults with and without SCI. Experiment 2 will examine how aging and spinal cord injury affect the body's ability to strengthen nerve pathways involved in movement. The investigators will compare two pathways that help control leg movement, the corticospinal and reticulospinal pathways, to determine whether aging affects these pathways differently and whether spinal cord injury has a greater effect on the corticospinal pathway.
Sites (1)
- Shirley Ryan Abilitylab, Chicago, Illinois, United States