What this means
Researchers plan to compare older women who take hormone therapy with those who do not. They want to see how hormones affect muscle decline and response to exercise. This is a trial that is still recruiting, so no results are available yet.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- Ages 50–70
- Where
- 1 site, including Michigan
The science
- Registered title
- Sex Hormones and Aging
- Trial ID
- NCT07848438 ↗
- Phase
- Not applicable
- Study type
- interventional
- Conditions
- Menopause, Menopausal Hormone Therapy, Aging
- What is tested
- HRT: High-Resistance Strength Training, Control: High-Resistance Strength Training
- Sponsor
- University of Michigan
- Ages
- 50 Years to 70 Years
- Dates
- First posted Sep 30, 2026 · updated Sep 30, 2026
Registry summary
This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training.
Age-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.
Sites (1)
- University of Michigan, Ann Arbor, Michigan, United States