What this means
Researchers planned to compare a blood measure of biological age in women who did and did not have a live birth after IVF. This registration has no results yet, so it does not tell us whether the test predicts success.
Plain-English summary written by an AI model from the registry listing.
- Status
- Completed
- Who can join
- Ages 18 and over
- Where
- 1 site
The science
- Registered title
- Epigenetic Clock to Predict Ovarian Aging and Live Birth in ART
- Trial ID
- NCT07875140 ↗
- Phase
- Not applicable
- Study type
- observational
- Conditions
- Infertility Assisted Reproductive Technology, Ovarian Aging
- What is tested
- Peripheral blood sampling for epigenetic age estimation
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Ages
- 18 Years to no maximum
- Dates
- First posted Oct 15, 2026 · updated Oct 15, 2026
Registry summary
Epigenetic clocks based on DNA methylation estimate biological age and are associated with age-related conditions, but they have not been validated for female fertility. This prospective, multicenter, observational, non-profit cohort study investigated whether epigenetic age, estimated from peripheral blood DNA methylation, differs between women undergoing in vitro fertilization (IVF/ICSI) who achieve a live birth and those who do not. In a predefined subgroup of 30 women under 40 years of age, epigenetic age was also assessed after ovarian stimulation. Participation did not change clinical management.
Sites (1)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy