How people get it: Sold as a supplement.
Part of Age reversal: clearing old cells
The basics
What it is
Fisetin is one of three flavonols that a review looked at for prostate and bladder cancer. Flavonols are a class of flavonoids, which are commonly found in fruit and vegetables.
How it's thought to work
The review found fisetin has been shown to prevent the activation of several signaling pathways that promote inflammation. The review reported fisetin improves mitochondrial function (the cell's energy parts) and promotes autophagy (cells clearing out waste).
What the research has found so far
The review's results imply a positive outlook for fisetin and the other substances as a possible Alzheimer's treatment. A review found fisetin can reduce cell injury in the heart, brain, kidney, and liver after blood flow is blocked and restored.
Sources: PubMed abstract: Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review. ↗ · PubMed abstract: Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review. ↗
Clears aged cells in mice. Human trials have only started.
On Fisetin and aging, PubMed lists 1 trial in people, 2 studies that watched people over time, 44 animal and lab studies. See the counts and searches
Stage 2 because there are 1 published trial and 37 registered trials in people, but no large ones yet.
A stage shows how far research has got, not whether it will work for you. How stages work
Side effects and risks
- The review of injury studies reported no significant side effects from fisetin.
- The cancer review found a low expected toxicity for these flavonols, including fisetin.
- A review of studies found fisetin reduced injury from blocked blood flow without any significant side effects.
Sources: PubMed abstract: Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review. ↗ · PubMed abstract: Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature. ↗
Amounts used in studies
What studies or labels describe, not a recommendation.
The cancer review said clinical trials are still needed to explore dosing for these flavonols.
Roughly what it costs
The 7 products we list that contain Fisetin cost from $37 to $95, as read from the makers' pages. See the products
Questions to ask your doctor
- Is Fisetin a sensible option for me, given my health and the medicines I take?
- Could Fisetin interact with any medicine or supplement I already take?
- What side effects should I watch for, and when should I stop or call you?
- Supplements aren't checked by the FDA before sale. Is there a brand or a third-party test seal you would trust?
- How would we tell whether it is helping, and when should we review it?
This is general information gathered from the sources listed, not medical advice. Talk to your doctor before starting anything new.
Products that contain it
Read from each maker's page. The research stage is for the ingredient, not proof that a product works.
| Product | Form | Fisetin per serving | Price | Per serving |
|---|---|---|---|---|
| Fisetin Pro Longevity Plus - 60 capsulesProHealth Longevity · maker's page ↗ | capsule | 125 mgserving: 1 Capsule | $37.0060 servings | $0.62 |
| Pure Fisetin - 250 mg, 60 capsulesProHealth Longevity · maker's page ↗ | capsule | 250 mgserving: 1 Capsule | $55.9560 servings | $0.93 |
| Qualia SenolyticQualia · maker's page ↗ | capsule | 1400 mgserving: 6 Vegetarian Capsules | $39.502 servings | $19.75 |
| Rapid Reset Multi-Senolytic - 30 capsulesProHealth Longevity · maker's page ↗ | capsule | 1,500 mgserving: 10 Capsules | $69.953 servings | $23.32 |
| NAD+ Cell Regenerator™ and Resveratrol Elite™Life Extension · maker's page ↗ | capsule | 2.22 mgserving: 1 vegetarian capsule | $45.00 | — |
| FisetinRenue By Science · maker's page ↗ | — | See label | $64.95 | — |
| Pure Fisetin SupplementDoNotAge · maker's page ↗ | capsule | See label | $95.00 | — |
Amounts, servings and prices are as each maker lists them on its own page, checked Oct 16, 2026. Price per serving is the price divided by the servings per container on the label; “—” means the page didn't say. A serving is the maker's serving size, not a recommendation.
What experts say
No expert views collected yet. Each one we add names the person and links to where they said it.
Recent research
Trials
ClinicalTrials.gov lists 37 registered trials that mention Fisetin, for any condition (the count in The science below). Here we show the ones about aging. See them all ↗
The science
Counted from PubMed and ClinicalTrials.gov on Oct 17, 2026, using one search for Fisetin in relation to aging. Each link opens the exact search.
- Randomized trials in people
- 0 search ↗
- Large trials (multicenter or phase 3)
- 0 search ↗
- Phase 3 trials
- 0 search ↗
- Trials in people
- 1 search ↗
- Studies that watched people over time
- 2 search ↗
- Animal and lab studies
- 44 search ↗
- Registered trials
- 37 search ↗
PubMed search used
fisetin[tiab] AND (aging[tiab] OR ageing[tiab] OR longevity[tiab] OR lifespan[tiab] OR "life span"[tiab] OR healthspan[tiab] OR "Aging"[mh] OR "Longevity"[mh] OR senolytic*[tiab] OR senescen*[tiab])
Counts are search results, so they include some records that only mention Fisetin. How we count
Cite or share this page
Longevity Verdict. (n.d.). Fisetin: Research stage and evidence. Retrieved October 17, 2026, from https://longevityverdict.com/treatments/fisetin
<iframe src="https://longevityverdict.com/embed/stage/fisetin" title="Fisetin: research stage on Longevity Verdict" width="340" height="72" style="border:0" loading="lazy"></iframe>
The badge shows this treatment's current research stage and links back here. It updates by itself when the stage changes.