What this means
This is a trial that is recruiting people, and no results have been posted yet. It will test whether fisetin and exercise together can help prevent frailty, which means growing weak and frail.
Plain-English summary written by an AI model from the registry listing.
- Status
- Recruiting
- Who can join
- See eligibility
- Where
- 6 sites, including California
The science
- Registered title
- Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors
- Trial ID
- NCT06113016 ↗
- Phase
- PHASE 2
- Study type
- interventional
- Conditions
- Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Early Stage Breast Carcinoma
- What is tested
- Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration
- Sponsor
- Jonsson Comprehensive Cancer Center
- Ages
- No minimum to no maximum
- Dates
- First posted Nov 2, 2023 · updated Jul 30, 2026
Registry summary
This phase II trial tests how well fisetin and exercise works in preventing frailty in breast cancer survivors. Fisetin is a natural substance found in strawberries and other foods and is available as a nutritional supplement. Nutritional supplements may be useful in eliminating cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage nearby healthy cells. Giving fisetin may eliminate senescent cells in patients with breast cancer undergoing physical activity.
Sites (6)
- UCLA Health Cancer Care in Alhambra, Alhambra, California, United States
- UCLA Health Beverly Hills Primary & Specialty Care, Beverly Hills, California, United States
- UCLA Health Burbank Primary & Specialty Care, Burbank, California, United States
- UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California, United States
- UCLA Health Primary Care in Marina del Rey, Marina del Rey, California, United States
- UCLA Health Primary Care in Pasadena, Pasadena, California, United States