Name: How much human evidence is behind 19 popular longevity supplements?
Creator: Longevity Verdict
Published: 2026-10-17
License: https://creativecommons.org/licenses/by/4.0/

What we found

None of the 19 has reached stage 4: none is approved by the FDA or recommended in a major guideline for aging. 3 reach stage 3, large studies in people (Berberine, Omega-3 fatty acids, Vitamin D); the other 16 are at stage 2, small studies in people. How stages work.
For 18 of 19, animal and lab studies outnumber randomized trials in people. The widest gaps: 114 animal and lab studies to 1 randomized trial for Alpha-ketoglutarate; 323 animal and lab studies to 4 randomized trials for Taurine; 318 animal and lab studies to 7 randomized trials for Pterostilbene.
Fisetin has no randomized trial in people on PubMed on its use for aging, though we list 5 products containing it.
6 of 19 have no meta-analysis (a study that pools earlier trials) on their use for aging: Alpha-ketoglutarate, Fisetin, GlyNAC, NR, Spermidine, Urolithin A.
Most products, least evidence: Fisetin: 5 products, 0 randomized trials; GlyNAC: 6 products, 1 randomized trial; NMN: 11 products, 7 randomized trials.
The most studied in people: Vitamin D (156 randomized trials, 34 meta-analyses) and Omega-3 fatty acids (127 randomized trials, 24 meta-analyses). More studies don't mean a supplement works for aging; they mean the question has been tested more.

This is a count of research, not a rating. It doesn't say whether any supplement works or is safe for you. Talk to your doctor before taking supplements.

All 19 supplements

Select a column to sort. Every number opens the search it came from. Download the data (CSV)


Vitamin D	Stage 3	156	34	331	210	603	4
Omega-3 fatty acids	Stage 3	127	24	1992	1282	658	4
Creatine	Stage 2	57	14	171	88	46	4
Collagen peptides	Stage 2	47	2	89	61	159	1
Berberine	Stage 3	34	9	128	73	247	2
Urolithin A	Stage 2	26	0	43	27	177	3
Resveratrol	Stage 2	23	6	247	165	505	11
CoQ10	Stage 2	17	1	396	228	237	4
NAD+ boosters	Stage 2	15	3	92	43	180	0
Quercetin	Stage 2	14	5	156	95	316	3
Astaxanthin	Stage 2	12	1	80	50	92	5
NR	Stage 2	8	0	127	58	46	15
Spermidine	Stage 2	8	0	38	20	205	3
NMN	Stage 2	7	3	55	27	134	11
Pterostilbene	Stage 2	7	1	23	12	318	5
Taurine	Stage 2	4	1	198	126	323	1
Alpha-ketoglutarate	Stage 2	1	0	22	13	114	1
GlyNAC	Stage 2	1	0	18	11	5	6
Fisetin	Stage 2	0	0	37	7	44	5

Method

Supplements: every supplement Longevity Verdict tracks (19), chosen because people commonly take them for aging. Their research stages are set by fixed rules from published records; see the rules.
Randomized trials, meta-analyses, animal and lab studies: PubMed records matching each supplement's search in relation to aging (the search is on each supplement's page), filtered by PubMed's own publication types. Counts are search results and can include papers that only mention a supplement.
Registered and completed trials: interventional studies on ClinicalTrials.gov matching each supplement, for any condition, so these are larger than the aging-specific PubMed counts.
Products we list: products on Longevity Verdict that contain the supplement, read from makers' own pages. Used only as a rough sign of how widely each is sold.
Date: counts as of October 17, 2026. Live, updated counts are on each supplement's page.

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Cite this page (APA)

Longevity Verdict. (2026). How much human evidence is behind 19 popular longevity supplements? Retrieved from https://longevityverdict.com/reports/longevity-supplements-evidence-2026

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The chart shows randomized trials in people next to animal and lab studies for each supplement, and links back to this report.